Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation
نویسندگان
چکیده
منابع مشابه
The G2019S LRRK2 Mutation is Rare in Korean Patients with Parkinson's Disease and Multiple System Atrophy
BACKGROUND AND PURPOSE The LRRK2 (PARK8; OMIM607060) substitution was recently identified as a causative mutation for Parkinson's disease (PD). The pathologic heterogeneity of LRRK2-positive patients suggests that mutation of the LRRK2 gene is associated with the pathogenesis of PD and Parkinson-plus disorders, such as multiple system atrophy (MSA). We previously reported that the G2019S LRRK2 ...
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Comment. Possessing an APOE ε4 allele is the most important genetic risk factor yet identified for sporadic AD and also significantly lowers onset age. It is therefore striking that despite their young age at onset, only 2 of our 10 biparietal patients were ε4-positive. While we believe that a lack of association between biparietal AD (or posterior cortical atrophy AD) and APOE ε4 genotype has ...
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ژورنال
عنوان ژورنال: npj Parkinson's Disease
سال: 2021
ISSN: 2373-8057
DOI: 10.1038/s41531-021-00175-w